Can we make an ISO of two drives (D and E)

[doer]

I'm sorry, we are not familiar with creating ISO, which is not within our scope of support. We just know you can use dism.exe to capture Windows as a WIM file. For more information on how to use dism.exe, please refer to the link below:
https://docs.microsoft.com/en-us/windows...single-wim

Thank you for the link